Please use ER for emergencies only. Keep the medication in a place where others cannot get to it. Using opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects may occur if you also drink alcohol or use other drugs that cause drowsiness or slow breathing. Methadone may cause a life-threatening heart rhythm disorder. Call your doctor at once if you have a headache with chest pain and severe dizziness, and fast or pounding heartbeats.
Methadone is also used as part of a drug addiction detoxification program. In people addicted to heroin or other narcotic drugs, methadone reduces withdrawal symptoms without causing the "high" associated with the drug addiction.
Your heart function may need to be checked during treatment. If you use opioid medicine during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks. Do not breastfeed. Methadone can pass into breast milk and cause drowsiness, breathing problems, or death in a nursing baby. Follow the directions on your prescription label and read all medication guides or instruction sheets. Never use methadone in larger amounts, or for longer than prescribed.
Tell your doctor if you feel an increased urge to use more of this medicine. Never share opioid medicine with another person, especially someone with a history of drug addiction. Keep the medicine where others cannot get to it. Selling or giving away this medicine is against the law. Dissolve the dispersible tablet in water, orange juice, or other citrus-flavored non-alcoholic beverage. Stir and drink this mixture right away. Never crush a pill to inhale the powder or inject it into your vein.
This could result in death. You should not stop using methadone suddenly. Ask your doctor before stopping the medicine. Store at room temperature, away from moisture, heat, and light.
Keep your medicine in a place where no one can use it improperly. Do not keep leftover medicine. Just one dose can cause death in someone using it accidentally or improperly.
Ask your pharmacist about a drug take-back program, or flush the unused medicine down the toilet. If you take methadone for pain: Take the missed dose as soon as you remember, then take your next dose 8 to 12 hours later. If you take methadone for drug addiction: Take your missed dose the next day at the regular time.
If you miss your doses for longer than 3 days in a row, call your doctor for instructions. You may need to restart methadone at a lower dose.
Seek emergency medical attention or call the Poison Help line at An overdose can be fatal, especially in a child or person using opioid medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.
Your doctor may recommend you get naloxone a medicine to reverse an opioid overdose and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up.
Your caregiver must still get emergency medical help and may need to perform CPR cardiopulmonary resuscitation on you while waiting for help to arrive.
Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it. Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Grapefruit may interact with methadone and cause side effects. Avoid consuming grapefruit products. Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. Serious breathing problems may be more likely in older adults and people who are debilitated or have wasting syndrome or chronic breathing disorders. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may have a fatal methadone overdose if you start or stop using certain other medicines.
Tell your doctor about all your medications. Many other drugs can be dangerous when used with opioid medicine. If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:. If your symptoms are severe, call or go to the nearest emergency room right away.
If you take this drug for pain and miss a dose, take it as soon as possible. Then take your next dose 8—12 hours later as directed by your doctor. Taking more than the prescribed dose may cause you to overdose because this drug builds up in your body over time.
How to tell if the drug is working: You should have decreased pain, or your withdrawal symptoms should go away. Taking it again could be fatal cause death. The use of drinks that contain alcohol can increase your risk of sedation, slowed breathing, coma being unconscious for a long time , and death from methadone. If you drink alcohol, talk to your doctor. You may need to be monitored for low blood pressure, breathing problems, and sedation.
For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of methadone in your body and cause more side effects. Your doctor should watch you closely if you take this drug.
For people with liver problems: If you have liver problems or a history of liver disease, you may not be able to process this drug well. For people with breathing problems: This drug can cause breathing problems. It can also worsen breathing problems you already have.
This can be fatal cause death. If you have breathing problems, severe asthma, or have an asthma attack, you should talk to your doctor about whether this drug is safe for you. For people with a gastrointestinal GI obstruction: This drug can cause constipation and increase your risk of a GI obstruction. If you have a history of GI obstructions or you currently have one, you should talk to your doctor about whether this drug is safe for you.
For people with seizures: This drug may cause more seizures in people with epilepsy. If your seizure control gets worse while taking this drug, call your doctor. For people with a head injury: This drug may cause increased pressure in your brain.
This can raise your risk of complications or cause death. Talk to your doctor about whether this drug is safe for you. Methadone can interact with several other medications. Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects.
Below is a list of medications that can interact with methadone. Before taking methadone, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.
Do not take the following drugs with methadone. Doing so can cause dangerous effects in your body. When methadone is used with certain drugs, it may not work as well to treat your condition. This is because the amount of methadone in your body may be decreased. Examples of these drugs include:.
You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled. You should mix it with 3 to 4 ounces 90 to milliliters of water or citrus fruit juice before you take it.
It takes about a minute to mix. You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:. There are restrictions on dispensing methadone for detoxification or maintenance programs. Not every pharmacy can dispense this medication for detoxification and maintenance.
Talk to your doctor about where you can get this drug. There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional.
You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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